ColdFusion CFMX7 Cumulative Hot Fix 2 big Error

Today the weirdest thing happened... we're running CFMX7 on our development servers for one big client, and have two clustered CFMX7 production servers too... I have the latest cumulative hot fixes on the Dev server and I realized that the production one wasn't patched... I've patched a few servers thus far, and they all worked perfectly fine afterwards... any hoo ... I update my production server and BAM! it goes down. I couldn't open any page... I was getting Null Pointers errors all over the place. After debugging and trying a few things I found that it was because I had an Application.cfc ... The weird thing is that it didn't matter what code I had there, any Application.cfc will generate Null Pointers errors... the same code works fine in my dev environment ... has any of you ever seen this behavior? I had to manually remove the hotfix 2 and install hotfix 1, which is what I'm running there now ... It really baffles me... Anyone else had problems with Hot Fix 2? Application.cfc ... null pointer errors?